December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Assessment of skin involvement in systemic sclerosis.
Authors:Kumanovics G, Pentek M, Bae S, Opris D, Khanna D, Furst DE, Czirjak L
Institution:Department of Rheumatology and Immunology, Medical School, University of Pecs, Pecs. Hungary. CA, USA. Pharmacy, Bucharest, Romania. Michigan, Ann Arbor, MI, USA. CA, USA. Pecs.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v53-v66. doi: 10.1093/rheumatology/kex202.

2:Points to consider in renal involvement in systemic sclerosis.
Authors:Galluccio F, Muller-Ladner U, Furst DE, Khanna D, Matucci-Cerinic M
Institution:Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, AOU Careggi, Florence, Italy. Giessen, Giessen. Kerckhoff-Klinik, Bad Nauheim, Germany. California, Los Angeles, Los Angeles, CA. Michigan, Ann Arbor, MI, USA. University of Florence, AOU Careggi, Florence, Italy.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v49-v52. doi: 10.1093/rheumatology/kex201.

3:Points to consider for skin ulcers in systemic sclerosis.
Authors:Galluccio F, Allanore Y, Czirjak L, Furst DE, Khanna D, Matucci-Cerinic M
Institution:Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, AOU Careggi, Florence, Italy. Publique-Hopitaux de Paris, Paris-Descartes University, Paris, France. California. Los Angeles, Los Angeles, CA. Michigan, Ann Arbor, MI, USA. University of Florence, AOU Careggi, Florence, Italy.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v67-v71. doi: 10.1093/rheumatology/kex200.

4:The limited cutaneous form of systemic sclerosis is associated with urinary incontinence: an international multicentre study.
Authors:John G, Allanore Y, Polito P, Piantoni S, Fredi M, Avouac J, Franceschini F, Truchetet ME, Cozzi F, Airo P, Chizzolini C
Institution:Department of Internal Medicine, Hopital neuchatelois, La Chaux-de-Fonds. Hospitals (HUG), Geneva, Switzerland. Italy. Italy. Italy. Bordeaux, France. Italy. Switzerland.
Journal:Rheumatology (Oxford). 2017 Nov 1;56(11):1874-1883. doi: 10.1093/rheumatology/kex230.

5:Predictors of lung function test severity and outcome in systemic sclerosis-associated interstitial lung disease.
Authors:Le Gouellec N, Duhamel A, Perez T, Hachulla AL, Sobanski V, Faivre JB, Morell-Dubois S, Lambert M, Hatron PY, Hachulla E, Behal H, Matran R, Launay D, Remy-Jardin M
Institution:Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), Lille, France.; Inserm, U995, Lille, France.; CHU Lille, departement de medecine interne et immunologie clinique, Lille, France.; Centre national de reference maladies systemiques et auto-immunes rares (sclerodermie systemique), Lille, France.; UDSL, EA 2694, UFR Medecine, Lille, France.
Journal:PLoS One. 2017 Aug 1;12(8):e0181692. doi: 10.1371/journal.pone.0181692. eCollection 2017.

6:Association between cigarette smoking and impaired clinical symptoms in systemic sclerosis: A review.
Authors:Zhang YJ, Zhang L, Huang XL, Duan Y, Yang LJ, Wang J
Institution:Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China. Electronic address:; Medical Genetics Center, Anhui Medical College, Hefei, China.
Journal:Cell Immunol. 2017 Aug;318:1-7. doi: 10.1016/j.cellimm.2017.04.002. Epub 2017 Apr 12.

7:Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model.
Authors:Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters PJ, King TE Jr, Collard HR, Lee JS
Institution:Department of Medicine, University of California, San Francisco, San Francisco, CA. Electronic address: Francisco, San Francisco, CA. CA. CA. CA. Francisco, CA. CA. CA. CA. CA. CA. CA. CA; Department of Medicine, University of Colorado Denver, Denver, CO.
Journal:Chest. 2017 Nov;152(5):999-1007. doi: 10.1016/j.chest.2017.06.009. Epub 2017 Jun 16.

8:Short-Term Pulmonary Function Trends Are Predictive of Mortality in Interstitial Lung Disease Associated With Systemic Sclerosis.
Authors:Goh NS, Hoyles RK, Denton CP, Hansell DM, Renzoni EA, Maher TM, Nicholson AG, Wells AU
Institution:Austin Hospital, Melbourne, Victoria, Australia, and Royal Brompton and Harefield NHS Foundation Trust, London, UK. Hospital, London, UK. UK. UK. UK. UK.
Journal:Arthritis Rheumatol. 2017 Aug;69(8):1670-1678. doi: 10.1002/art.40130. Epub 2017 Jul 18.

9:Self-reported physical capacity and activity in patients with systemic sclerosis and matched controls.
Authors:Pettersson H, Akerstrom A, Nordin A, Svenungsson E, Alexanderson H, Bostrom C
Institution:a Department of Medicine , Karolinska Institutet , Solna , Sweden.; b Functional Area Occupational Therapy and Physiotherapy, Allied Health Professionals Function , Karolinska University Hospital , Stockholm , Sweden.; c Department of Neurobiology, Care Science and Society, Division of Physiotherapy , Karolinska Institutet , Stockholm , Sweden.; d Unit of Rheumatology , Karolinska University Hospital , Stockholm , Sweden.
Journal:Scand J Rheumatol. 2017 Nov;46(6):490-495. doi: 10.1080/03009742.2017.1281436. Epub 2017 Mar 17.

10:"It's Not Me, It's Not Really Me." Insights From Patients on Living With Systemic Sclerosis: An Interview Study.
Authors:Sumpton D, Thakkar V, O'Neill S, Singh-Grewal D, Craig JC, Tong A
Institution:University of Sydney, Sydney, The Children's Hospital at Westmead, Westmead, Liverpool Hospital and Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia. and Western Sydney University, Campbelltown, New South Wales, Australia. Applied Medical Research, Liverpool, New South Wales, Australia. Institute for Applied Medical Research, Liverpool, New South Wales, Australia. New South Wales, Australia. New South Wales, Australia.
Journal:Arthritis Care Res (Hoboken). 2017 Nov;69(11):1733-1742. doi: 10.1002/acr.23207. Epub 2017 Oct 9.

11:Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial.
Authors:Coghlan JG, Galie N, Barbera JA, Frost AE, Ghofrani HA, Hoeper MM, Kuwana M, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Blair C, Gillies H, Miller KL, Harris JHN, Langley J, Rubin LJ
Institution:Cardiology Department, Royal Free Hospital, London, UK. of Bologna, Bologna, Italy. Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. Hannover, Germany. Medicine, Tokyo, Japan. Pneumologie, AP-HP, Centre de Reference de l'Hypertension Pulmonaire Severe, Hopital de Bicetre, Le Kremlin Bicetre, France. Therapeutique (LERMIT), UMR_S 999, INSERM, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.
Journal:Ann Rheum Dis. 2017 Jul;76(7):1219-1227. doi: 10.1136/annrheumdis-2016-210236. Epub 2016 Dec 30.

12:Personalized Physical Therapy Versus Usual Care for Patients With Systemic Sclerosis: A Randomized Controlled Trial.
Authors:Rannou F, Boutron I, Mouthon L, Sanchez K, Tiffreau V, Hachulla E, Thoumie P, Cabane J, Chatelus E, Sibilia J, Roren A, Berezne A, Baron G, Porcher R, Guillevin L, Ravaud P, Poiraudeau S
Institution:AP-HP Cochin Hospital, Universite Paris Descartes Sorbonne Paris Cite, and INSERM U1153, Paris, France.; AP-HP Hotel Dieu Hospital, Universite Paris Descartes Sorbonne Paris Cite, and INSERM U1153, Paris, France.; Reference Center for Rare Diseases, AP-HP Cochin Hospital, and Universite Paris Descartes Sorbonne Paris Cite, Paris, France.; Reference Center for Rare Diseases, Lille University Medical Center, University of Lille 2, Lille, France.; AP-HP Rothschild Hospital and Pierre and Marie Curie University, Paris, France.
Journal:Arthritis Care Res (Hoboken). 2017 Jul;69(7):1050-1059. doi: 10.1002/acr.23098. Epub 2017 Jun 7.

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